Members of the Centre for Research in Biosciences

Director

Name Key research interests

Professor Aniko Varadi

Centre Director and Professor of Biomedical Science

Professor Dawn Arnold

Deputy Director and Professor in Molecular Plant Pathology

Biomedical Genetics, Type 2 Diabetes.

 

 

Molecular plant pathology.

   

Staff members

Name Key research interests

Dr Emmanuel Adukwu

Lecturer in Microbiology

Community acquired infections, hospital acquired infections, biofilms, antimicrobial agents, essential oils, disinfection.

Dr Chris Alford

Associate Professor in Applied Psychology

Sleep, psychopharmacology, performance, sleep loss and fatigue, driving, natural products and functional foods, social drugs, psychophysiological measures including actimetry and EEG.

Dr Joel Allainguillaume

Senior Lecturer in Molecular Genetics

Ecological Risk Assessment of GM crops, crop improvement, environmental monitoring and DNA barcoding.

Dr Elizabeth Anderson

Post Doctoral Research Fellow

Acute Myeloid Leukaemia, bacterial bioluminescence biosensors, cell biology.

Dr Jackie Barnett

Research Fellow

Control of disease through the development of novel biosensor technologies for use in rapid point-of-care diagnostics. Particular areas of interest include development of magnetic detection technologies using paramagnetic particles and development of diagnostics for infectious diseases, cancer and Alzheimer’s with novel biomarkers.

Dr Sam Bonnett

Senior Lecturer in Environmental Science

Biogeochemistry, extracellular enzyme activities, greenhouse gas production, biochar, wetlands.

Dr Carrie Brady  Microbial taxonomy.

Dr Man-Kim Cheung

Technician

Molecular biotechnology, recombinant gene expression and transformation systems, reporter gene development.

Professor Myra Conway

Professor of Biomedical Science

Clinical biochemistry, metabolic biochemistry, the role of the branched chain aminotransferase (BCAT) proteins in glutamate toxicity, a key contributor to the pathogenesis of neurodegenerative disorders such as Alzheimer’s Disease.

David Corry

Laboratory manager - Biomedical Research

Laboratory manager.

Dr Adrian Crew

Research Fellow

Bio-sensors, environmental monitoring, food analysis.

Dr Tim Craig

Senior Research Lecturer, Physiology

The role of protein SUMOylation in glucose homeostasis and type-II diabetes. 

My work is on the role of post-translational modifications of proteins in the control of glucose homeostasis and the pathology of Type-II Diabetes. In particular, I am interested in a poorly understood modification called SUMOylation, which has many roles in different cellular functions, and has been associated with diseases as diverse as cancer and Alzheimer’s disease. My previous work has shown that SUMOylation is intimately involved in neurotransmitter release and neurotransmitter detection in the brain, processes which utilise strikingly similar cellular machinery to insulin secretion and glucose uptake.

Over the last few years, there has been a steady trickle of evidence in support of a role for SUMOylation in the regulation of blood glucose, and also suggestions that this process may be altered in Type-II diabetes. However, the role of SUMOylation in these processes and how they become defective in disease is unknown. My work seeks to elucidate these mechanisms and thus potentially identify new drug targets for Type-II Diabetes.

Dr Victoria Davenport

Senior Lecturer

Mucosal immunology.

Dr Ben de Lacy Costello

Senior Research Fellow

Chemical sensors and targeted sensor arrays for disease diagnosis, biomarker identification using SPME and ATD coupled with GCMS, chemical computing using the Belousov Zhabotinsky reaction, pattern forming reactions.

Sarah Dean

Senior Lecturer - Healthcare/Biomedical Science

 Breast cancer and cellular pathology.
 Professor Olena Doran

Associate Dean (Research) and Professor in Biomedical Research 

Molecular mechanisms of food quality in relation to human health, identification of biomarkers and development of genetic tests for pathological states and food quality, lipid metabolism.

Dr Farnon Ellwood

Senior Lecturer - Environmental Biology

Environmental sciences and ecology, evolutionary biology.

Dr David Fernandez

Lecturer

In my research I use a multidisciplinary approach to monitor and study wildlife populations, identity and evaluate conservation threats, and translate the results of these studies into informed policy recommendations. Most of my work has been in Bioko Island, Equatorial Guinea, and in the Udzungwa Mountains of Tanzania. Currently, I am developing large-scale biomonitoring programs to remotely monitor wildlife, detect illegal human activity and identify priority areas for conservation at both sites. I also work extensively with local communities, developing environmental education and outreach activities.

Emeritus Professor John Greenman

Professor of Microbiology

Microbial fuel cells, oral malodour, in vitro biofilms, growth, ecology and physiology of microbes: biofilm and planktonic continuous culture.

Dr John Hancock

Associate Professor in Molecular Biology, Associate Head of Department (RKE)

The production and role of reactive oxygen and reactive nitrogen species, as well as hydrogen sulfide, in biological systems with a focus on cell signalling.

Dr Hancock has been listed by Thomson Reuters as a 'Highly Cited Reseacher'.

Professor John Hart

Professor in Biosensor and Electroanalytical Sciences

Disposable screen-printed electrochemical sensors and biosensors for applications in biomedicine, environmental studies and agri-food analysis; HPLC/Electrochemical detection for the determination of trace levels of vitamins, coenzymes and drugs.

Dr Antony Hill

Senior Lecturer

Stability analyses in sustainable energy production, medicine and biology, blood flow in the microcirculation, solar ponds; nonlinear energy theory.

Dr Annabelle Hodson

Senior Lecturer

 Chemistry.

Dr Kevin Honeychurch

Research Fellow

Electrochemistry, sensors, chromatography, HPLC, GC, GC/MS.

Dr Jonathon Hull

Research Technician

 Radioacivity, Protein Biochemistry, Physiology.

 

 

Professor Tony Killard

Professor of Biomedical Sciences

Development of chemical sensors, biosensors and biomedical diagnostic devices. Application of novel electroactive materials (nanostructured conducting polymers and electrocatalysts) to electrochemical sensors and biosensors, while also making these amenable to low-cost mass production using technologies such as screen printing, inkjet printing and polymer MEMS fabrication. Integration of these sensors into functional diagnostic devices and systems eg point of care diagnostics using novel techniques such as breath monitoring and printed electronics technology.

Dr Kris Kinsey

Senior Lectuer

Biological and cognitive markers of development related disorders such as dementia (Alzheimer’s disease), autism and dyslexia.

Dr Michael Ladomery

Reader in Biomedical Science

Alternative splicing in cancer, regulation of alternative splicing through the SR protein kinase SRPK1, the oncogenic splice factor SFRS1, alternative splicing of VEGF, HER2, H-Ras, Insulin Receptor and ERG, role of the TMPRSS2/ERG microdeletion in prostate cancer, the tumour suppressor gene WT1 in development and disease, the stress-associated RNA-binding protein atGRP7/RBM3, identification of plant-derived compounds with splicing modulatory activity.

Dr Lynne Lawrance

Senior Lecturer in Medical Microbiology and Programme Leader for MSc in Biomedical Science 

Moraxella cattarhalis (a pathogen of the mucous membranes such as the respiratory tract, eyes and inner ear), the molecular epidemiology of pathogenic bacteria, biomedical ethics and philosophy.

Dr Debbie Lewis

Molecular Biology/ Immunology Technician

Microbial fuel cells, Microbiology, Molecular Biology, Urinary Tract.

Dr Katy Ling

Senior Lecturer

Effects of air pollution on tree health, woodlands and calcareous grasslands, impacts of trees on urban air quality, development of environmental policy within the electricity industry, use of science in environmental policy development, effect of legislation on the implementation of environmental policy, public understanding of Global Climate Change.

Professor Richard Luxton

Director Institute of Bio-Sensing Technology

Developing new rapid diagnostic technologies for point of care diagnostics and environmental analysis, magnetic immunoassay and whole cell impedance and imaging, working with industry and developing academic / industrial collaboration and networking.

Dr Heather Macdonald

Senior Lecturer in Molecular Biology

Auxin perception; signal transduction and proteomic responses to biotic and abiotic stresses; microalgal biofuels.

Dr Jason Mansell

Senior Lecturer - Biomedical Science

Osteoblasts, differentiation, active vitamin D3, titanium functionalisation, lysophosphatidic acid (LPA) and LPA analogues.

Dr Pete Maxfield

Lecturer in Enviornmental Chemistry

Biogeochemistry,  organic geochemistry, stable isotopes, mass spectrometry.

Dr Jennifer May

Lecturer in Biomedical Science

Haematology, bone marrow, stem cell transplantation, chemotherapy.

Professor David McCalley

Professor in Bioanalyitical Science

High performance liquid chromatography (HPLC) and gas chromatography (GC) to the solution of problems especially in biomedical and pharmaceutical science.

Dr Natasha McGuire

Research Support Technician

Sensor development and testing:  volatile analysis, metal oxide semiconductors, electrochemical, biosensors, gas chromatography and screen-printing.  Applications: detection of carbon dioxide and diagnosis of C.difficile, Norovirus, IBD & IBS.

Dr Chris Moore

Senior Lecturer, Anatomy & Physiology

Anatomy, Physiology, creating e-learning resources for scientific and medical education, dental science.

Dr Phil Morgan

Senior Lecturer in Psychology

 

 Effects of interruptions and distractions on task performance (including aging effects and memory/attention/stress disorders),  

Effects of emotive stimuli and emotion on task performance (including physiological and brain activity measurement, methods to alter the brain basis of emotion regulation, effects of sleep, stress and distress)

Developing methods to encourage adaptive change to deep rooted cognitive strategies in memory, planning and problem solving

Developing methods to alleviate biologically based impairments in the performance of spatial awareness tasks (specifically mental rotation)

Developing psychologically informed principles for designing displays used in safety critical settings  

Dr Ruth Morse

Senior Lecturer

The molecular biology of stem cell transplantation, the aetiology of haemopoietic malignancy.

Dr Carolyn Morton

Senior Lecturer 
Forensic  Sciences

 

 

Forensic Science especially fingerprint enhancement techniques, Forensic Toxicology and the use of Virtual Worlds for Forensic Science Learning and Teaching.

 

Dr Helen Neale

Research Fellow

Molecular Genetics and Microbiology; molecular plant-microbe interactions.

Professor Steven Neill

Deputy Dean

Reactive oxygen and nitrogen species and cell signalling, abscisic acid physiology, biochemistry and molecular biology, molecular and cell biology of stomatal guard cells.

Professor Neill has been listed by Thomson Reuters as a 'Highly Cited Reseacher'.

Dr Shona Nelson

Lecturer

Bacterial biofilms, Pseudomonas aeruginosa, bioluminescence as a monitor of bacterial metabolic activity, probiotics.

Dr Lyn Newton

Head of Department of Applied Sciences

Detecting stress in marine invertebrates and fish, the use of biomarkers, sub-lethal effects of oil pollution on echinoderms, the predictive capacity of toxicity tests, the effects of long-term exposure to metal contamination on marine invertebrates.

Dr Mario Orsi

Senior Lecturer

 

 Biomolecular modelling, molecular dynamics simulation, interfaces, lipids, membranes, water, proteins, permeation

Dr Keith Page

Research Associate

Bacterial bioluminescent biosensors to access chemotherapy treatment in cancers.

Dr Carolyn Paul

Senior Lecturer

The pharmacology of the functional and dysfunctional blood-brain barrier in response to disease and toxicological stresses, current projects relating to glutamate excitotoxicity in neurological conditions where there is a neurovascular component, namely Alzheimer’s disease and Multiple Sclerosis, also the nanotoxicity of nanoparticles at the blood-brain and placental barriers.

Dr Roy Pemberton

Senior Lecturer

Developing novel biosensors by combining biological recognition elements (antibodies/enzymes) with electrodes, use of screen-printing technology to fabricate electrodes from carbon-containing inks as the basis for electrochemical sensing devices, applying enzyme biosensors to monitor cell metabolism in culture.

Dr Martina Piano

Research Fellow

Electrochemistry, Sensor, biosensor, material science, enzyme stabilisation, analytical chemistry, elisa assay, magneto immuno sensor.

Dr Sean Porazinski

Research Fellow

ERG splicing in prostate cancer, manipulation of alternative splicing of oncogenes for therapeutic applications, cancer cell biology, live cell imaging.

Dr David Qualtrough

Senior Lecturer

Tumour invasion and metastasis, wound healing in inflammatory disease.

Professor Norman Ratcliffe

Professor in Materials and Sensors Science

Volatile analysis, sensor and device fabrication and testing of commercial sensors, aerospace industry, molecular electronics, nuclear industry.

Professor Darren Reynolds

Professor of Health and Environment

Dissolved organic matter flourescence and water quality, biological and chemical decontamination in healthcare environments using electrochemically activated solutions, visualisation of biological and chemical processes using low light detection and imaging.

Dr Gareth Robinson

Lecturer

My research interests involve the applications of bacterial bioluminescence, the transfer of genes from naturally bioluminescent bacteria to bacteria which affect human health offers a unique mechanism through which the metabolism of bacterial cells can be monitored. I have experience in genetic modification of human pathogens with plasmid-borne bacterial lux genes, detection of expression and using these recombinant bioluminescent reporter strains as whole-cell bioreporters. I have utilised bioluminescent reporter species for: monitoring the efficacy of antibiotics; in transcytosis and invasion assays, in coculture with human cell lines; to monitor the effect of novel biocides in real time in situ using a range of detection technology; to develop an assay to monitor the efficacy of fast acting biocides, in real time; to assess the in vitro efficacy of a novel anti-leukaemic drug. My research using biocides has developed into assessing novel delivery mechanisms such as aerosol technology, novel biocide technologies including non thermal plasma, utilising both wild-type human pathogens and genetically modified bioluminescent bacterial reporter strains.

 Dr Vivien Rolfe


Associate Head of Department (Biomedical, Biological and Healthcare Science)

Interests include STEM education research and open education. Research methods expertise includes qualitative and quantitative approaches and systematic review.

Dr Saliha Saad

Senior Research Fellow

Oral malodour, in vitro biofilm models, clinical trials to study the anti malodour effects of medicated formulations (malodour counteractives), microbiology of exfoliative surfaces.

Emerita Professor Vyv Salisbury

Professor of Applied Microbiology

Use of bioluminescent clinical strains of significant bacterial pathogens for evaluation of the pharmacodynamic effects of antibiotics, use of bacterial bioluminescence as an intracellular reporter, use of bioluminescent strains of food borne pathogens for evaluation of heat treatment of foods, uffect of low dose macrolide antibiotics on bacterial cell signalling.

Dr Eleni Siasou

Research Associate

Predicting the plant uptake of radionuclides using “phylogeny" and “ionomics". Studying the effects of acute and low level chronic radiation on environmental microorganisms.

Dr Peter Spencer-Phillips

Academic Director, International and Research and Asscoiate Professor in Applied Microbiology

Microbiology of food spoilage and plant disease.

Dr Mark Steer

Lecturer

Monitoring the impacts of conservation efforts at the landscape level. Potential of Payments for Ecosystem Services as a funding mechanism for lowland wetlands. Impact of species reintroductions on ecological function.

Dr Karina Stewart

Senior Lecturer - Physiology

 Exercise physiology, exercise and health.
Dr Rhian Thomas

Senior Lecturer in Human Physiology

Alzheimer’s disease, antibody-based therapies, underlying mechanisms of disease, neruodegeneration, molecular neurosciences, cell biology and biochemistry.

Dr Robin Thorn

Post Doctoral Researcher

 Applied Microbiology.

Dr Andy Tubb

Programme Leader - Environment

Environmental research.

Dr Dann Turner

Research Associate

 Bacteriophage biology and genomics.

Dr Bahareh Vahabi

Lecturer - Physiology

Physiological and pharmacological function of lower urinary tract in health and disease. Development of isolated animal bladder models for studying the integrative physiology of the bladder.

Dr Jim Vafidis

Lecturer

My research interests are the impacts of environmental change on wetland and upland ecosystems, focusing on behavior, physiology and population dynamics. I have a working interest in data analysis and statistics, using ecological models to address applied issues in industry, wildlife management and conservation.

Dr Gabrielle Wheway

Lecturer- Biomedical Science

Cell biology, genetics and molecular mechanisms of disease in inherited developmental and degenerative conditions associated with primary cilia (the ciliopathies). Particular interest in those ciliopathies affecting the central nervous system, including retina.

Dr Trevor Whittall

Senior Lecturer in Haematology

The general area of my research is Immunology, with subheadings of Auto-immunity, Vaccines and Viral Immunity, Inflammatory Diseases, Macrophage Biology and Amyloid Disease.

My current research includes work on :- Oxidative stress in Pulmonary Disease, Innate and Adaptive Immunity to HIV (correlates of protection), and Bioinformatic approaches to identifying triggers of autoimmune disease.

Professor Neil Willey

Professor of Environmental Plant Physiology and Director of UWE Graduate School

Radionuclides, heavy metals and organics in the soil-plant system. Predicting the uptake and effects of contaminant radionuclides for food contamination studies and environmental assessments. The use of phylogenetic, ionomic and molecular techniques to understand the behaviour of toxic inorganics in plants.

Dr Ian Wilson

Senior Research Fellow

Cell signalling, ethylene, re-active oxygen species.

Dr Kathryn Yuill

Senior Lecturer -Healthcare Science

My research interest centres on investigating changes in cardiovascular ion channel function induced by disease states and by pharmacological modulation. I am particularly interested in understanding the relationship between ion channel function and calcium release in cells of the cardiac conduction system, and how ion channel function is altered in diseases like Diabetes.

PhD students

 

Name Title of PhD
Hanan Alabouh 'Regulation of alternative splicing in Leukaemia by the Splice Factor Kinase SRPK1'
Layla Al Hajab 'Role of the GRP RNA binding proteins in stress adaptation in Chlamydomonas reinhardtii'
Sultan Almalki ‘Optimisation of haematopoietic stem cell homing post-transplantation, using an in vitro model of the bone marrow/vasculature interface’
Elizabeth Bowler 'The effect of hypoxia on alternative splicing in prostate cancer'
Nicol Caplin ‘NERC Radioactivity and the Terrestrial Environment (RATE) programme studentship: the biological effects of ionizing radiation’
Claire Caygill 'The role of pancreatic islet cell glutamate receptors in endocrine hormone secretion and in the development of diabetes'
Gillian Clayton ‘The development of off-grid water treatment technologies for the recovery of agricultural wastes’
Mike Devey 'Investigating biomarkers of triple negative breast cancer'
Julian Donald ‘What is the relationship between biodiversity and ecosystem function?’
Arwa Flemban 'Investigation of New Tissue Biomarkers for Triple Negative Breast Cancer'
Amy Forward 'The use of thermal desorption techniques to establish a suitable quantitative method of analysing drugs on money'
Bethany Fox ‘The development of fluorescence sensing for monitoring microbial processes in freshwater systems’
Mark Fraser ‘Novel Approaches to the Detection of Antifungal Resistance in Candida spp’
Oliver Gould ‘The detection of trace volatiles as potential biomarkers of disease using gas chromatography mass spectrometry (GCMS) techniques and selected ion flow tube mass spectrometry (SIFT-MS) assessment of volatiles produced from nitric oxide producing smart dressings’
Keith Hewett ‘In vitro modelling of tongue microbial biofilms and their response to treatments’
Fred Hudd ‘Regulation of neurotransmitter synthesis in Alzheimer’s disease – potential for dietary supplements to improve cognition’
Samantha Jumbe ‘Targeting the splice factor kinases SRPK1 and CLK1 in prostate cancer’
Saeed Kabrah 'Development of a three-dimensional physiologically relevant model of the bone marrow; comparison of in-vitro functionality with bone marrow from in-vivo chemotherapy treated lymphoma and leukaemia patients'
Marian Manso ‘Fluid reabsorption across bladder urothelium’
Bertrand Monnier ‘Development of a rapid and cost effective ‘on-site’ detection method for Cacao Swollen Shoot Virus (CSSV)’
Janet Mundy 'Individual Differences in Spatial Abilities and Task Strategy'
Kelechi Okeke ‘Exploration of a chemotherapy induced bystander effect in the aetiology of therapy related or donor cell leukaemia’
Grace Okoro ‘The impact of alcohol and toxic metabolites on neurotransmitter synthesis and protein misfolding in neurodegenerative conditions.’
Joseph Payne ‘Quantum Pathogen evolution by integron-mediated effector capture’
Josie Phillips ‘Does the relationship between biodiversity and ecosystem function change during conversion of tropical forest to oil palm plantation?’
Mai Shafei ‘Biomarkers and therapeutic targets for solid tumours’
Elisabeth Slade ‘Biofilms in wounds; using microbial metabolomics for the rapid diagnosis of wound infection.’
Richard Thompson 'Investigating the Efficacy of Bacteriophage Therapy for Preventing the Encrustation and Blockage of Urinary Catheters'
Wilasinee Triyarat 'Developing a Regional Framework for Science Communication Activities in Thailand'
Andrew Turner 'Development and application of gene scanning techniques for the diagnosis of a thalassaemia trait or traits'
Simon Uzor ‘Analogy of the Prostrate Specific Antigen of Smokers’
Kelly Westmacott ‘Novel technology (bio-sensors) for boar taint detection to assist with projection of taint-free pork’
Chigeru Wodi ‘An investigation into the function of the splice factor kinase SRPK1’

 

Professional doctorates

Name Title
Khaled Abuzariba 'Vitamin D status in type 2 diabetic patients with various degrees of glycaemic control'
Sephora Aquilina 'Development of in vitro long term cultures of erythroblasts for transfusion purposes'
Emmanuel Azore 'Molecular characterisation and virulence determinants of research models associated Staphylococcus aureus (RMA-SA)'
Elanne Christie 'Identifying and measuring key constraints impacting on the five Clinical Compliance Officers in the Scottish National Blood Transfusion Service in achieving regulatory compliance with the Blood Safety and Quality Regulations (BSQR) through the theoretical lens of Activity Theory'
Paradzai Chitongo 'A prospective case-control study to investigate the prothrombotic phenotype of severely obese patients'
Susan Davey 'A novel genotyping approach to improve transfusion support for patients with HLA and/or HPA alloantibodies'
Jeni Davies 'Developing a strategy for red cell antigen typing and matching of blood for transfusion in chronically transfused patients'
James Dowds 'Mechanisms of Tumour Progression from Ductal Carcinoma in-situ (DCIS) to Invasive Carcinoma'
Wendy Etheridge 'Development of a novel automated assay for the detection of antibodies to red cell antigens'
Ivo Fombon 'Role of cystatin C in the evaluation of renal function in patients receiving fenofibrate treatment for dyslipidaemia'
Matthew Griffiths 'Data monitoring if key performance indicators can be used to ensure quality of histological dissection performed by Biomedical Scientists'
Noel Jereza 'The Incidence of Coexistent Hepcidin (HAMP)/HFE Haemochromatosis Gene Mutations and Iron Overload in Irish Patients with Dilated Cardiomyopathy (DCM)'
Zacharias Kallis 'Investigation of the quality of cord blood units and the isolation of progenitor cells from umbilical cord tissue processed and cryopreserved as cellular therapy products by an international family cord blood bank'
Jonathan Lewis 'The Incidence and Molecular Characteristics of Clinical Escherichia coli Isolates Producing AmpC Beta-lactamase Enzymes'
Linda Matthews 'Exploring the implications of changing patterns of Rubella immunity in antenatal women in South Wales Valley Community'
Sherina Murden 'The use of Next Generation DNA sequencing for the molecular diagnosis and characterisation of Hermansky Pudlak Syndrome'
Nigel Oakes 'The expression of Toll like receptors on T and B Lymphocytes in Chronic Lymphocyctic Leukaemia; links with prognosis and association with autoimmune disease'
Samantha Osmond 'Quantification of cannabinoids by novel HPLC methods to distinguish frequency from duration since last use'
Anthony Poles 'Glycoprotein estimation and analysis of genes associated with inherited platelet disorders and complications of pregnancy'
Janet Wells 'A study of regulatory T cells and clinical outcome in patients undergoing haematological transplantation'
 

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