Projects in the Centre for Research in Biosciences

Researchers in the centre have secured funding for projects that have resulted in real scientific, social and economic benefits.

We are currently undertaking a range of projects.

Read more about the differences some of our projects are making

The Role of Protein SUMOylation in Glucose Homeostasis and Type-II Diabetes

Dr Tim Craig at UWE Bristol is looking into novel mechanisms involved in the pathology of type-II diabetes and the regulation of blood glucose levels.

What are the environmental consequences of converting rainforest to oil palm plantation?

Researchers from CRIB are currently working as part of the Southeast Asia Rainforest Research Partnership (SEARRP) to investigate the environmental impacts of oil palm expansion. The aim is to improve the understanding of rainforest conversion to oil palm and to develop new strategies to improve the sustainability of the industry.

Understanding the molecular biology of inherited eye disease

Dr Gabrielle Wheway from UWE's Centre for Research in Biosciences has been awarded funding from the Wellcome Trust and National Eye Research Centre (NERC) to investigate a specific group of proteins which are mutated in retinitis pigmentosa, the most common cause of inherited blindness.

Targeting the oncogene ERG in prostate cancer with splice switching oligonucleotides

Dr Michael Ladomery from UWE's Centre for Research in Biosciences is currently developing splice switching oligonucleotides (SSOs) targeted against the ERG oncogene, and oncogene that is activated in a staggering proportion (~50%) of prostate cancers.

Enhancing bone implant performance and longevity through novel surface functionalisations

Dr Jason Mansell from UWE's Centre for Research in Biosciences is currently developing superior, multi-functional bone biomaterials for orthopaedic and dental applications.

Transfer, Exposure, Effects: Understanding Radioactivity in the Environment

Researchers from CRIB are part of a consortium investigating the movement and effects radioactivity in the environment. The aim is to improve significantly predictions of radionuclide behaviour so that safety assessments have a secure scientific basis. The consortium is part of the NERC Radioactivity and The Terrestrial Environment (RATE) programme.

The diarrhoea diagnostic device: from bench to bedside

Researchers from the Department of Applied Sciences are working to produce a device that can confirm the presence of disease by smell, with a £1.3 million award from the Wellcome Trust.

Can we delay the progression of Alzheimer's Disease?

Researchers from the Centre for Research in Biosciences are working with the charity BRACE on a project that may lead to earlier interventions that slow or even prevent progression of Alzheimer’s Disease.

Developing a rapid test for organophosphate pesticide contamination

Working with industry colleagues, researchers from the centre have developed screen-printed amperometric biosensors that could lead to a rapid test for toxic organophosphate pesticides in food and water supplies.

Understanding how plant antimicrobial "hot zones" can accelerate pathogen evolution

UWE Bristol (Professor Dawn Arnold) has teamed up with the Universities of Oxford (Dr Gail Preston) and Reading (Dr Robert Jackson) to win a £500,000 grant to study ways of increasing crop yields by reducing disease.  The award from the Biotechnologies and Biological Sciences Research Council (BBSRC) enables researchers to build on recent discoveries about how disease spreads in bean plants. The 3-year project could result in developing new ways to prevent diseases in this valuable food crop.

Identification and taxonomy of bacteria associated with Acute Oak Decline

Native oak species in Britain are being attacked by a disorder known as Acute Oak Decline (AOD). UWE scientists, Dr Carrie Brady and Professor Dawn Arnold, are now working in collaboration with Dr Sandra Denman of the Centre for Forestry and Climate Change and the charity Woodland Heritage to investigate the causes of this devastating disease.

Paper-thin device to test cholesterol levels

The SIMS project is an European Commission FP7 collaboration on the development of a Smart Integrated Miniaturised Sensor (SIMS) system using integrated organic and printed electronics technologies.  Partners to this €2.95M project, which is led by UWE, include Dublin City University, University of Liverpool, Fraunhofer ENAS, VTT and Alere. This technology integrates printed sensors, displays, batteries and organic circuits into a single, disposable device.  

Currently, the project has developed an operational prototype capable of measuring cholesterol and which can be used in conjunction with mobile phone technology to transmit the test result to a remote location, allowing effective healthcare management.

For more information on this project and it's partners please see the latest news release

The SIMS project is also featured in the latest edition of International Innovation which is a print and online journal for dissemination of science and technology research and development.

 

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