Centre for Research in Biosciences (CRIB)

The CRIB (Centre for Research in Biosciences) laboratory suite consists of three labs - the main research lab, the tissue culture lab and the flow cytometry and cell imaging lab (2G16).

Key facilities

  • The main lab has all the usual lab equipment (balances, centrifuges, etc) plus liquid nitrogen freezers which hold their cell line stocks. The groups working in the main lab cover research areas such as leukaemia, diabetes, development of molecular diagnostic techniques, inflammation and immunology, stem cells, in vitro modeling and development and biosensor development.
  • The tissue culture laboratory is, as the name suggests, a lab solely dedicated to the establishment and maintenance of the mammalian cell lines used in many biomedical research projects. Equipment here includes four CO2 incubators to keep the cells alive and three Class 2 bio-safety cabinets for the safe and sterile handling of cells, blood and clinical samples. Their cell lines are primarily used to simulate disease states (e.g. tumours) or tissues (in vitro modeling) which can then be studied at a cellular level.
  • The third lab (flow cytometry and cell imaging) holds most of the 'big' analytical equipment and includes fluorescence and confocal microscopes, flourescence and absorbance plate readers, a surface plasmon resonance (SPR) detector for the detection and measurement of protein binding, an ageing scanning densitometer and a flow cytometer/fluorescence activated cell sorter (FACS) which uses flourescent probes to detect and measure a variety of cellular parameters. This instrument will sort cells expressing a desirable characteristic from a mixed cell population.

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